Guo investigates cellular mechanisms of self-organization in biological
systems, particularly the biomechanics that enhance and stabilize spatiotemporal
control, where collective locomotion usually leads to integrated global
behaviors. A current project investigates how a single cell polarizes
along a unique axis, with a focus on cytoskeleton-mediated processes.
He is also interested in the transport mechanism for multi-cell group
motion, which appears in embryogenesis, tissue development, and wound
healing. His lab plans to combine techniques of advanced optics, clean-room
fabrication, and molecular biology to identify these mechanisms. Theoretical
models using statistical mechanics and nonlinear dynamics combined
with experimental results are also in progress.