Suppressing Brownian Motion of Single Molecules in Solution

Adam Cohen
Stanford University

To study a single molecule in solution, one would like to hold the molecule still without perturbing its dynamics along internal degrees of freedom. The Anti-Brownian Electrokinetic trap (ABEL trap) uses single-particle tracking and real-time electrokinetic feedback to cancel the Brownian motion of one molecule of interest. I will discuss how one can glean new types of information from trapped molecules, focusing on the polymer dynamics of DNA.

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